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| 1851 |
| | English photographer Frederick Scott Archer publishes the details of his collodion process, a marked improvement on the earlier calotype negative | |
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| 1851 |
| | German physicist Hermann von Helmholtz invents the ophthalmoscope, making it possible for a doctor to examine the inside of a patient's eye | |
| | Principle of Helmholtz's ophthalmoscope Wellcome Library, London
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| 1853 |
| | The hypodermic syringe with a plunger is simultaneously developed in France and in Scotland | |
| | Alexander Wood's hypodermic syringe Wellcome Library, London
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| 1854 |
| | US inventor Elisha Otis dramatically demonstrates his new safety elevator, cutting the rope suspending his platform in New York's Crystal Palace | |
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| 1857 |
| | The Haughwout Store, a five-storey building in New York, instals the first Otis safety elevator | |
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| 1858 |
| | US entrepreneur Cyrus W. Field succeeds in laying a telegraph cable across the Atlantic, but it fails after only a month | |
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| c. 1860 |
| | German chemist Robert Wilhelm Bunsen and technician Peter Desdega perfect the non-luminous gas burner for use in the laboratory | |
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| 1867 |
| | The invention of barbed wire is patented in the USA by Lucien Smith, designed to fence in cattle but also a protection for the wheat fields of the midwest plains | |
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| 1867 |
| | Swedish chemist Alfred Nobel patents dynamite, making the volatile explosive nitroglycerine safer by combining it with kieselguhr | |
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| 1871 |
| | Italian US immigrant Antonio Meucci files a patent in New York for the invention of the telephone | |
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